"Our findings seem to suggest one of the very good predictors for how well you'll do over the long term is how much your personality changes in response to the medication," he said. "For example, how much your neuroticism improved predicted how likely you were to relapse in a year after the treatment."
Bernard Carroll, scientific director of the Pacific Behavioral Research Foundation in Carmel, Calif., said any excitement over the results should be tempered by the fact that the improvements in depression from taking paroxetine weren't much better than from a placebo or cognitive therapy.
The study findings are published in the December issue of Archives of General Psychiatry.
Extraversion, which is associated with positive emotions, is believed to help protect from depression, while neuroticism, the tendency to experience negative emotions and emotional instability, is thought to contribute to depression.
relapse within a year of halting medications, while about 45 percent to 50 percent relapse even if they're still on medication, Tang said.
By Jennifer ThomasMONDAY, Dec. 7 (HealthDay News) Taking antidepressants may not only help alleviate depression, but could make you more extraverted and less neurotic, new research suggests.
Antidepressants May Change Your Personality
Relapsing after stopping treatment, or even while still receiving treatment, is a problem for people with depression. About two thirds of patients Nike Sneakers Photos
It wasn't that the depressed patients suddenly became happy go lucky, carefree social butterflies, Tang said. On scales of extraversion and neuroticism, their levels were still barely in the normal range but they were better than they were before.
serotonin reuptake inhibitor. Other SSRIs include Prozac, Zoloft and Celexa. Though those drugs were not tested, Tang said the impact on the personality would likely be similar.
The researchers divided 240 adults with a major depressive disorder into three groups: Nike Shoes Blue And Gray
All groups experienced some improvement in their depression. But participants taking paroxetine became less neurotic and more extraverted than those receiving cognitive therapy or placebo.
Deciding whether to take Nike Sneakers Men 2018 an SSRI or not has to be weighed against possible side effects, Carroll said, citing a recent study in the British Journal of Psychiatry that found that many people taking SSRIs reported feeling that the medications had blunted their emotions, both negative and positive ones. Other side effects may include headache, changes in sleep patterns, gastrointestinal upset and changes in sexual functioning, according to background information in that study.
Extraversion and neuroticism are associated with the serotonin system, the brain's reward center that helps regulate mood, sleep and appetite. In this study, participants took paroxetine, which is sold under the brand name Paxil, a selective Nike Shoes 2018 For Men
Instead, paroxetine is more commonly prescribed for anxiety disorders, which is why researchers may have noted the personality changes. "Paroxetine wouldn't be anybody's number one choice for depression," Carroll said. "But it just might make sense that improving certain personality dimensions helps the patient's resilience against future relapse."
"People's personalities actually do change and quite substantially when they go through these antidepressant treatments," Tang said. "In the past, we tended to dismiss the personality changes as a side effect or something not very important. But our study suggests it's actually very important to treatment outcomes."
120 received paroxetine, 60 underwent cognitive therapy and 60 took a placebo. Personalities and depressive symptoms were assessed before, during and after treatment.
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