study findings, Dr. Joel Zonszein, director of the clinical diabetes center at Montefiore Medical Center in New York City, said: "Complications of diabetes can be very bad, and some patients do very well on Actos."
This isn't the first time the drug has been associated with heightened odds for bladder cancer: A study published May 31 in BMJ found that taking Actos for two years can double the risk.
A number of studies have found that taking certain diabetes medications from a class of drugs known as thiazolidinediones appears to increase that risk even more. Actos is a thiazolidinedione, as is the drug known as Avandia (rosiglitazone). These medications are used in type 2 diabetes because they make the body more sensitive to insulin, which reduces the level of insulin the body needs. Because these drugs reduce the amount of available insulin, Johnson said he suspects the link between Actos and bladder cancer would have to be the result of a direct effect of the medication.
In the current analysis, Johnson and his colleagues reviewed the available data on thiazolidinediones and bladder cancer in type 2 diabetes. They included 10 studies in their analysis that had more Nike Shoes Grey And Black
Another Study Links Diabetes Drug Actos to Bladder Cancer
Results of the new study are published July 3 in CMAJ (the Canadian Medical Association Journal).
By Serena GordonTUESDAY, July 3 (HealthDay News) There's more evidence that people with type 2 diabetes may have an increased risk of bladder cancer, and taking the diabetes drug Actos may raise that risk even higher.
People with type 2 diabetes have a 40 percent increased risk of developing bladder cancer, according to background information in the current analysis. This increased risk is believed to be associated with high levels of insulin found in people with type 2 diabetes. Insulin is a hormone that helps the body turn carbohydrates from food into sugar (glucose) that can be used for fuel. Nike Sneakers White Black
"The bladder cancer risk appears to be real, but is pretty small. If you're not at risk of bladder cancer in the first place, the benefits of pioglitazone [Actos] may outweigh the potential risk," Johnson said.
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Johnson added that it's important to keep in mind that bladder cancer is a relatively rare cancer, and even with the increased risk, any one person's risk of bladder Nike Golf Shoes Black And Yellow cancer "is pretty small."
Insulin is also a growth hormone, and cancer cells have insulin receptors on them, which means they can use insulin to grow, according to Johnson.
than 2.6 million people. From that group, 3,643 people were newly diagnosed with bladder cancer.
Johnson said it's not clear yet how Actos might raise the risk of bladder cancer, but he said some animal studies suggested that the drug could cause crystals to form that irritate the bladder, which could potentially play a role in the development of bladder cancer.
Not all of the studies found a link between Actos and bladder cancer. One randomized controlled trial, which is the type of study considered the "gold standard" for such research, found no association. Overall, they found a 22 percent increased risk of bladder cancer with the use of Actos.
Taking pioglitazone (brand name Actos) raised the risk of bladder cancer by about one fifth, according to a new analysis of previously completed studies. However, the individual risk of getting bladder cancer still remained quite low. Johnson, the Canada Research Chair in Diabetes Health Outcomes at the University of Alberta School of Public Health, in Canada.
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